ENDOTOXIN TOLERANCE. I. ITS INDUCTION BY EXPERIMENTAL PYELONEPHRITIS*

Endotoxin Tolerance. I. Its Induction by Experimental Pyelonephritis.

Induction of RelB participates in endotoxin tolerance.

Using a THP-1 human promonocyte model of endotoxin tolerance that simulates the sepsis leukocyte phenotype, we previously showed that tolerant cells remain responsive to LPS endotoxin with degradation of IkappaB in the cytosol and nuclear translocation and accumulation of p50 and p65 NF-kappaB transcription factors. Despite this, endotoxin-inducible NF-kappaB-dependent innate immunity genes, li...

Experimental Pyelonephritis

Uncomplicated pyelonephritis in man is almost always produced by a single species of bacteria, ordinarily a Gram-negative organism. Mixed infection of the urinary tract is usually associated with chronic obstruction or instrumentation. In animals the production of pyelonephritis results in an acute process, and in most models a single species of bacteria has been used as the infecting agent. It...

Experimental Pyelonephritis

A study has been made of the effect of ureteral ligation on the susceptibility of the kidney to pyogenic infection. In most experiments a strain of E. coli was employed as the test organism, being injected intravenously in varying quantity either before or after ureteral ligation. A few experiments were also carried out with S. marcescens. Preliminary observations were made on the distribution ...

Early-phase endotoxin tolerance: induction by a detoxified lipid A derivative, monophosphoryl lipid A.

After a sublethal exposure to lipopolysaccharide (LPS) or to lipid A, which is that portion of the LPS molecule associated with endotoxicity, a transient period ensues during which a normally responsive individual is rendered hyporesponsive to LPS-induced toxicity. This period has been defined as early-phase endotoxin tolerance. Recently, a nontoxic derivative of lipid A from Salmonella typhimu...